• For a long time the

  2021-09-22

  

  For a long time, the mechanism for the TG-lowering effect of nicotinic BMN-673 has been thought that the lowered NEFA substrate from adipose tissue limits TG production from the liver (so-called NEFA hypothesis) [[1], [2], [3], [4]]. However, recent emerging evidences have suggested the involvement

• Recognition and Repair of DNA Damage DNA

  2021-09-22

  

  Recognition and Repair of DNA Damage DNA is a reactive molecule that is continually challenged by both endogenous and exogenous insults 1., 2.. Cellular metabolites and their byproducts, environmental toxins, and radiation alter the chemical structure of DNA, producing a wide spectrum of DNA damage

• br Regulation of Glu transporters The

  2021-09-22

  

  Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino Solamargine synthesis calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been described. These includ

• br Materials and methods br

  2021-09-22

  

  Materials and methods Results Discussion Employment of GIPR signaling, specifically the direction of this manipulation, as a strategy to improve body weight remains a contentious subject of intense scientific investigation [22], [32], [33]. Despite the physiological benefits of GIP on meclo

• Introduction Parkinson s Disease PD is a neurodegenerative d

  2021-09-22

  

  Introduction Parkinson's Disease (PD) is a neurodegenerative disease affecting approximately 5–6 million individuals worldwide [1]. This number is expected to escalate to ∼10 million by the year 2030 as the world's population rapidly ages [2]. In the United States, more than 1 million individuals h

• br Concluding remarks In this small

  2021-09-18

  

  Concluding remarks In this small material of thirteen pituitary tumors of various kinds, we could not run statistical analysis. However, with a follow-up period of up to five years, we show that Disclosure Statement Acknowledgments Introduction Galanin is a 29/30-residue neuropeptide fo

• In summary although there are still several important

  2021-09-18

  

  In summary, although there are still several important questions open on the mechanisms that trigger FAK nuclear localization and FAK-dependent gene regulation, Cardoso et al. (2016) provide important new insights on FAK/MEF2-mediated initiation of cardiac hypertrophy. Acknowledgments The author

• The suboptimal trypsin selectivity profile of DPC p http www

  2021-09-18

  

  The suboptimal trypsin selectivity profile of DPC423 prompted us to investigate additional P moieties for potency and selectivity. Glycinamide P () showed low nanomolar binding affinity against fXa which suggested that this P moiety sits deeper into the S pocket of fXa. To further elaborate on this

• naloxone hydrochloride receptor FXa is a vitamin K dependent

  2021-09-18

  

  FXa is a vitamin K-dependent serine protease consisting of two chains linked by a disulfide bridge. The heavy chain contains 303 naloxone hydrochloride receptor and the light chain has 139 amino acids. The catalytic triad comprised of Ser195, His57, and Asp102  exhibits the trypsin-like β-barrel st

• This SAR work led to

  2021-09-18

  

  This SAR work led to the identification of compound 10r ((±)-2-[3-fluoro-4-[3-(hexylcarbamoyloxy)phenyl]phenyl]propanoic acid, ARN2508) [51] as a potent in vivo active inhibitor of intracellular FAAH and COX activities, which exerts profound anti-inflammatory effects in mouse models of IBD without c

• The above mentioned studies are especially important since t

  2021-09-18

  

  The above-mentioned studies are especially important since the structural alterations of the peritoneum during peritoneal dialysis are very similar to vascular and tissue alteration seen in diabetes. The tissue alterations during long-term peritoneal dialysis include a thickening and replication of

• br Memories can last a lifetime

  2021-09-18

  

  Memories can last a lifetime, long after the transient events have passed. The fact that information stored in the BMS-626529 can outlast the environmental trigger implies that enduring cellular changes in the central nervous system underlie memory. Epigenetic modifications of DNA and chromatin s

• A series of P P ureas were

  2021-09-18

  

  A series of P3-P4 ureas were explored first and their anti-NS3 protease activity, antiviral properties in a HCV replicon cell-based assay and PK profiles examined. Installation of a methyl group on the P4 side nitrogen dna staining of the urea yielded , a molecule which retained intrinsic potency ag

• Regulation of gene expression in mammalian cells is

  2021-09-18

  

  Regulation of gene expression in mammalian cells is governed by the epigenetic machinery, which includes several distinctive yet entangled branches. DNA and histone modifying enzymes, non-coding regulatory RNAs, and ATPase-dependent chromatin remodeling proteins all contribute to the dynamic alterat

• Acetylation of histones by histone

  2021-09-18

  

  Acetylation of histones by histone acetyltransferases stimulates gene expression by relaxing ras inhibitor structure, allowing access of transcription factors to DNA, whereas deacetylation of histones by histone deacetylases promotes chromatin condensation and transcriptional repression. Recent stu

15788 records 567/1053 page Previous Next First page 上5页 566567568569570 下5页 Last page